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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018



Vetcast Workshop 2018

Determination of clinical breakpoints / Modelling and simulation of pharmacokinetic data

22 & 23 June 2018 Wroclaw (Poland)

2 one-day workshops

Workshop 1 : determination of clinical breakpoints

Download program June 22, 2018

Time Activity - Presented by L. Pelligand and tutors
9h00 – 9h45 VetCAST approach to clinical breakpoint
9h45 – 10h30 Defining wild type distribution
ECOFF: practical exercise
10h30 - 11h00 Coffee break
11h00 – 11h45 What is an MIC? Monte Carlo appraisal
11h45 – 12h30 Introduction to population pharmacokinetics
12h30 – 13h30 Lunch   
13h30 – 15h00 Exercise 2: Step by step building of a population model with Phoenix to estimate typical PK values and random parameters to establish PK/PD cut-off of florfenicol 
15h00 - 15h30 Afternoon break
15h30 – 16h00 Continued and debriefing
16h00 – 16h45 Determination of PD parameters for florfenicol using a semi-mechanistic model and in silico dose fractionation
16h45 – 17h00 End of the workshop, concluding remarks

Workshop 2: Modelling and simulation of pharmacokinetic data

Download program June 23, 2018

Time Activity
  Nonlinear mixed-effects (NLME) models - Dr. Jonathan Mochel
09:00 – 09:30 Introduction
  Concept and definitions
  Exploiting patients’ characteristics to explain variability in drug exposure
  Model building, evaluation and validation
09:30 – 10:00 Applications in Veterinary Medicine
10:00 – 10:30 Coffee break
10:30 – 12:00 Software demonstration
  Available software
  Hands-on example: Florfenicol pharmacokinetics
12:00-13:00 Lunch Break
  Physiological-based pharmacokinetic (PBPK) models - Prof. Ronette Gehring
13:00 – 14:00 Introduction
  What are PBPK models?
  How are they different from other PK models?
  What are the advantages and disadvantages of this approach to PK modeling?
14:00 – 15:00 Demonstration of a basic PBPK model using Berkley Madonna
15:00 – 15:30 Coffee break
15:30 – 16:30 Practical aspects
  Data sources
  Steps to building a PBPK model
16:30 – 17:00 Applications of PBPK models, including demonstrations of examples