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INRA
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Dernière mise à jour : Mai 2018

Menu INRA Eucast ENVT ECVPT ANR

Workshop on veterinary antimicrobials for microbiologists and pharmacologists, college residents, regulatory authorities, pharmaceutical companies...

VETCAST 2017 workshop

Antimicrobial susceptibility testing with VETCAST breakpoints: quantitative methods

12-15 SEPTEMBRE 2017 TOULOUSE (France) - Hotel Mercure Centre Compans, boulevard Lascrosses, 31000 Toulouse

Conference and Workshop

12 September : overview on VETCAST current standards on AST in veterinary medicine

13-15 September: workshop on the main tools used to determine clinical breakpoints (lectures and practical exercises)

Tuesday 12 September 2017

9:00 am - 5:00 pm : The first-day conference

09:00-9:15 Meet & Greet – An overview of the course (Pierre-Louis Toutain/Dik Mevius)
09:15-10:00 Lecture 1 Current standards for AST in veterinary medicine (Dik Mevius)
10:00-10:30 Lecture 2 Introduction to VETCAST: objectives, current achievements and future plans (Peter Damborg)

11:00-11:45 Lecture 3 CLSI / VAST approaches and experiences (Marilyn Martinez)
11:45-12:30 Lecture 4 Tools for testing: present and future (including innovations in rapid bedside, genetic and other tests) (Alex van Belkum)

Lunch

13:30-14:15 Lecture  5 The setting of clinical breakpoints by VETCAST   (Pierre-Louis Toutain)
14:15-15:00 Lecture  6  Overview on determination of ECOFF, PK/PD breakpoint  and clinical cut-offs (Pierre-Louis Toutain/Alain Bousquet-Melou/John Turnidge)

15:30-16:00 Lecture7 CEESA position and questions (Hilde Moyaert)
16:00-17:00 Open questions and discussion with stakeholders (Peter Lees /Dik Mevius (moderators))

Wednesday 13 September 2017

9:00 am - 5:00 pm : The 3-day workshop

Wednesday 13 September 2017:  ECOFF and introduction to  PK/PD  and clinical cut-offs

9:00-9:30 Lecture 8 MIC wild type distributions and epidemiological cut‐off values: human and veterinary perspectives John Turnidge/Kees Veldman
09:30-10:30 Lecture 9 Methods for defining the wild type distribution (determining the ECOFF) John Turnidge
10:30-11:00 Morning break
11:00-12:15 Exercise 1 ECOFF: practical exercise John Turnidge
12:15-13:45 Lunch
13:45-14:45 Lecture 10 PK/PD indices and experimental in vitro and in vivo approaches: an overview Alain Bousquet-Melou/Aude Ferran
14:45-15:05 Lecture 11 Determination of potency indices in differing matrices Peter Lees
15:05-15:35 Lecture 12 Clinical trials and clinical cut-off for AST: an overview and current issues Pierre-Louis Toutain
15:35-16:05 Lecture 13 Clinical cut-off: the CLSI approach (Maxdif and Window expert system tools) Marilyn Martinez
16:05-16:30 Afternoon Break
16:30-17:00 Lecture 14 Statistics associated with validation of tests and ROC curves Didier Concordet
17:00-18:00 Exercise 2 Computation of specificity and  selectivity of tests; building a ROC curve; computation of positive and negative predictive values and diagnostic gain of  tests Didier Concordet

Thursday 14 September  2017: Population modelling and PK/PD cut-offs

8:45-9:30 Lecture 15 Population modelling: an introduction Pierre-Louis Toutain and Didier Concordet
9:30-10:30 Exercise 3 Step-by-step building of a population model with Phoenix© to estimate typical PK values and random components to establish PK/PD cut-offs and computation of an individual AUC using a Bayesian approach for the computation of a clinical cut-off Pierre-Louis Toutain, Didier Concordet and tutors
10:30-11:00 Morning break
11:00-12:00 Exercise 3 Continued  
12:00-13:30 Lunch
13:30:15:00 Exercise 4 Simulation of dosage regimens using the population model and determination of corresponding PK/PD cut-offs Pierre-Louis Toutain and tutors
15:00-15:30 Afternoon  break
15:30-16:30 Exercise 4 Continued Pierre-Louis Toutain and tutors
16:30-18:00 Exercise 5 Monte Carlo Simulations using Crystal Ball  and computation of dosage regimens with Target Attainment Rates Ludovic Pelligand

Friday 15 September 2017: PK/PD and Clinical cut-offs & clinical  breakpoint

8:30-9:15 Lecture 16 How to analyze classical killing curves to compute critical values of PK/PD indices (Emax model…) Lena Friberg
9:15-10:00 Lecture 17 How to select  PK/PD indices and estimate target values using semi-mechanistic models (demonstration) Lena Friberg
10:00-10:30 Morning break
10:30-11:15 Lecture 18 Classical PK/PD indices re-visited by semi-mechanistic models (  the case of long-acting drugs and formulations)  and future trends  in human medicine Lena Friberg
11:15-12:00 Lecture 19 Classification and regression tree analysis and logistic regression Didier  Concordet
12:00-13:30 Lunch
13:30-14:15 Exercise 6 A logistic regression analysis with Phoenix© Pierre-Louis Toutain/Ludovic Pelligand
14:15-15:00 Exercise 7 A regression tree analysis with R Didier  Concordet
15:00–15:30 Afternoon  break
15:30-16:00 Lecture 20 The VETCAST SOP and Excel sheet  for PK data collection: discussion and update Moderators : Ludovic Pelligand, Peter Lees, Pierre-Louis Toutain
16:00-16:45   End of the workshop and de-briefing Moderators : Pierre-Louis Toutain,  Peter Lees